Charcot Marie Tooth Disease

CMT is hereditary peripheral nerve degenerative disease. Due to DNA mutations of peripheral motor nerves and sensory nerves, which results in axonal and myelin sheath damage, patients present nerve function loss, distal muscle weakness of limbs, muscle atrophy, accompanied by feet deformity, ankle joint deformity, and sensory disturbance. At late stage, the disease can progress very fast, resulting in total paralysis. It is a progressive disease.